The MedMain goal is to advance engineering science and technology to enhance healthcare. Specifically, MedMain applies advanced robotics, manufacturing, and design for safety, quality, efficiency, and economy in healthcare service and research. MedMain balances fundamental science and clinical applications, producing research articles and patents, scientists, and entrepreneurs. Some representative projects are high-speed grinding inside human arteries to clear the blockage and treat cardiovascular diseases, high-speed machining of a blood clot inside the human brain to treat stroke, a tele-ultrasound imaging system with intuitive user interfaces, robotic catheterization for neuro intervention, mechanical testing of a blood clot, atherosclerotic plaque, and brain tissues, hydrodynamic flexible-shaft polishing for 3D printed internal channels.